a 66 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2418	A66		PI3K
	A66 is a specific and effective p110α inhibitor(IC50=32 nM).		PI3K
T15654	Ketohexokinase inhibitor 1	PF-06835919	Others
	Ketohexokinase inhibitor 1 is a ketohexokinase inhibitor (IC50s: 8.4 nM and 66 nM for KHK-C and KHK-A, respectively).		Others
T67853	Rivaroxaban Impurity	Rivaroxaban-10	Factor Xa
	Rivaroxaban Impurity (Rivaroxaban-10) is a potent Blood-coagulation factor Xa inhibitor, IC50= 66 nM.		Factor Xa
T9744	MP07-66		Phosphatase
	MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.		Phosphatase
T8260	4',5-Dihydroxyflavone		Lipoxygenase , Glucosidase
	4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).		Lipoxygenase , Glucosidase
T7256	4-Chlorothieno[3,2-d]pyrimidine
	4-Chlorothieno[3,2-d]pyrimidine is a useful organic compound for research related to life sciences. The catalog number is T7256 and the CAS number is 16269-66-2.
T12616L	CE3F4		cAMP
	CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1; IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively).		cAMP
T10608	BRD5648	(R)-BRD0705	GSK-3
	BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705. BRD0705 is a GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM) and can be used in acute myeloid leukemia (AML) studies.		GSK-3
T62758	PKM2 activator 2		PKM
	PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabol...		PKM
T62404	SHMT-IN-2		Others
	SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell ly...		Others
T10606	BRD0705		GSK-3
	BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM).		GSK-3
T4578	Tipranavir	PNU-140690	SARS-CoV , HIV Protease
	Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple...		SARS-CoV , HIV Protease
T4021	UNC3866		Histone Methyltransferase
	UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.		Histone Methyltransferase
T8477	IQ-3		JNK
	IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an...		JNK
T20187	Alizarin Cyanine Green F	NSC41838,NSC-41838,NSC 41838	Others
	Alizarin Cyanine Green F (NSC-41838) is an agent of green dye. It can be used to dye paper, chromed leather, wool, silk, and nylon (acid bath), to stain wood, and to color anodized aluminum, urea-melamine resin, and soap...		Others
T12664	(Rac)-BRD0705		Others
	(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.		Others
T6733	WZ-3146		EGFR
	WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).		EGFR
TP1775L	LL-37, Human acetate(154947-66-7 free base)		Antibacterial
	LL-37, Human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.		Antibacterial
T2271	SBE13 Hydrochloride	SBE 13 hydrochloride,SBE 13 HCl	Apoptosis , PLK , Autophagy
	SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.		Apoptosis , PLK , Autophagy
T2514	Linifanib	ABT-869,RG3635,AL-39324	Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
	Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...